Endocrine Abstracts

Parathyroid glands regulate bone metabolism through PTH, while bone modulates parathyroid function through calcium and FGF23. Bone releases the matrix protein osteocalcin (OC), whose hormone function is increasingly evident. We tested the hypothesis that OC may modulate parathyroid function. The 6 hours-stimulation of human parathyroid cells derived from adenomas (PAds) (n = 5) with γ-carboxylated OC (GlaOC; 40–60 ng/ml) increased the expression levels ...

Parathyroid glands regulate bone metabolism through PTH, while bone modulates parathyroid function through calcium and FGF23. We tested the hypothesis that the matrix protein osteocalcin (OC), secreted by osteoblasts, may modulate parathyroid function. In human parathyroid cells derived from adenomas (PAds), incubation with g-carboxylated OC (GlaOC) or undercarboxylated OC (GluOC) modulated the intracellular signaling pathways: both GlaOC and GluOC inhibited the basal phosphor...

The Hippo pathway is involved in human tumorigenesis and regeneration. Here, we investigated the Hippo co-activator YAP1 and the kinase LATS1/2 in tumors of the parathyroid glands, which are almost invariably associated with primary hyperparathyroidism. Compared with normal parathyroid glands (n = 3), where YAP1 was detectable in the cytoplasm and in the nucleus, parathyroid adenomas (PAds; n = 10) had YAP1 accumulation mainly at the nuclear level, while in p...